Although the determinism is unknown, psoriasis is attributed to an autoimmune part. In view of the involvement of the intestinal microbiota in the regulation of immunity, scientists are now following the trail of the microbiota to better understand psoriasis and perhaps treat it more effectively.
A still limited understanding
the psoriasis touches, according to the estimates of theWHO (World Health Organization), nearly 100 million people in the world and continues to progress. The pandemic of Covid-19 would have darkened the picture considerably, inducing new cases and aggravating the symptoms of patients already declared. No wonder, since this skin disease is known to be closely linked to mental dispositions, as stress, anxiety and depression.
In the light of the growing link brought to light in recent years between the intestinal microbiota and many chronic disorders (hyperlipidemia, diabetes, arthritis)recent studies have confirmed the important link between gastrointestinal and skin health. The results show that people prone to psoriasis very frequently have an altered composition and functioning of their microbiotafrom which results, in particular, a disruption of the SCFA production cycle (short chain fatty acids or short-chain fatty acids), important molecules with anti-inflammatory properties.
Psoriasis associated with a degraded microbiota
The disturbances of the microbiota observed in patients with psoriasis could be the cause of autoimmune conditions often associated with this disease. Research finds that populations of bacteria of the species Prevotellafor example, are commonly higher or lower in psoriasis than in a healthy microbiota.
Other strains (Phascolarctobacterium, Dialister, Escherichia, Akkermansia muciniphila, Faecalibacterium, Ruminococcus…), sometimes too abundant, sometimes understaffed, also seem to be involved in the development of psoriasis. These changes in populations affect in particular the production of butyrate (one of the main SCFAs), involved in the regulation of many anti-inflammatory agentss (such as lipopolysaccharides, TNF-α, IL-10 and IL-1ß).
The physiological and symbolic causes of psoriasis
Food, priority lever
Psoriasis remains a disease difficult to deal with. Some allopathic medicines, such as interleukin blockersnot content with being ineffective, can even participate in themicrobiota damage. Also the possibility even of alleviating its symptoms by acting on the microbiota, therefore food, she raises a lot of hope. According to recent work, of the dietary interventions induced notable and reproducible changes in the immune systemsuggesting a real potential to improve the immunological status as well as the functioning of the microbiome.
The typical Western diet (or western diethypercaloric and based on processed products of low nutritional quality) is unfavorable to the intestinal flora and facilitates the inflammation underlying psoriasis. Certain additives in particular, such as polysorbate 80 (or E433, emulsifier), the carboxymethylcellulose (or E466, thickener, binder and gelling agent) and the maltodextrin (thickener, bulking agent and preservative), are suspected of break the integrity of the intestinal tissues and facilitate their damage.
On the other hand, studies have shown that the fermented foodsfor example, have made it possible to reduce levels of 19 different pro-inflammatory agents (certain cytokines, chemokines, interleukins). the mediterranean diet is also favorable to a diversified and balanced microbiota. We can also add a series of natural remedies that will strengthen the reach of food interventions.
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